Pier M. Biava, Silvia Canaider, Federica Facchin, Eva Bianconi, Liza Ljungberg, Domenico Rotilio, Fabio Burigana and Carlo Ventura
Abstract: In spite of the growing body of evidence on the biology of the Zebrafish embryo and stem cells, including the use of Stem Cell Differentiation Stage Factors (SCDSFs) taken from Zebrafish embryo to impact cancer cell dynamics, comparatively little is known about the possibility to use these factors to modulate the homeostasis of normal human stem cells or to modulate the behavior of cells involved in different pathological conditions. In the present review we recall in a synthetic way the most important researches about the use of SCDSFs in reprogramming cancer cells and in modulating the high speed of multiplication of keratinocytes which is characteristic of some pathological diseases like psoriasis. Moreover we add here the results about the capability of SCDSFs in modulating the homeostasis of human adipose- derived stem cells (hASCs) isolated from a fat tissue obtained with a novel-non enzymatic method and device. In addition we report the data not yet published about a first protein analysis of the SCDSFs and about their role in a pathological condition like neurodegeneration.
Sonoluminescence, or its more frequently studied version known as Single Bubble Sonoluminescence, consisting in the emission of light by a collapsing bubble in water under ultrasounds, represents one of the most challenging and interesting phenomenon in theoretical physics. In fact, despite its relatively easy reproducibility in a simple laboratory, its understanding within the commonly accepted picture of condensed matter remained so far unsatisfactory. On the other hand, the possibility to control the physical process involved in sonoluminescence, representing a sort of nuclear fusion on small scale, could open unthinkable prospects of free energy production from water. Different explanations has been proposed during the past years considering, in various way, the photoemission to be related to electromagnetic Zero Point Field energy dynamics, by considering the bubble surface as a Casimir force boundary. More recently a model invoking Cherenkov radiation emission from superluminal photons generated in quantum vacuum has been successfully proposed. In this paper it will be shown that the same results can be more generally explained and quantitative obtained within a QED coherent dynamics of quantum vacuum, according to which the electromagnetic energy of the emitted photons would be related to the latent heat involved in the phase transition from water’s vapor to liquid phase during the bubble collapse. The proposed approach could also suggest an explanation of a possible mechanism of generation of faster than light (FTL) photons required to start Cherenkov radiation as well as possible applications to energy production from quantum vacuum.
Abstract: Living organisms are high ordered and organized systems accumulating and successively using low entropy energy to support all the processes needed for life. This low level of entropy is a re- quired condition in order to make possible the use of endogenous energy for producing, for example, mechanical work. The commonly accepted picture of condensed matter physics, exclusively consi- dering the perturbative coupling between QED Zero-Point-Field also known as “Quantum Vacuum” and the matter system, is unable to thoroughly explain the true origin of this low entropy energy reservoir and its dynamics. Recent researches instead suggested that energy and mass of every particle or body could be actually considered as arising from Quantum Vacuum dynamics which, in turn, can exhibit, under suitable conditions always occurring in the case of living systems, a coherent behavior characterized by a strong phase correlation between matter and an electromagnetic field trapped inside this ensemble. In this paper the preliminary model of Quantum Vacuum already proposed by author is reformulated in terms of QED coherence in condensed matter showing it is able to explain the origin of internal energy stock of living organisms. Within this theoretical framework, an interpretation of some important experimental results about biophotons emission by living systems under the influence of external stimuli is also proposed, suggesting their origin could also arise from Quantum Vacuum dynamics. This model, as shown, opens very interesting and exciting scenarios of further developments in the understanding of the birth and dynamics of life.
This article summarizes the scientific knowledge in the fields of quantum physics and of medical science about the origin and the nature of universe and of life. The recent discoveries in the field of biopsychic, genetic, epigenetic, neuroscience and psychosomatic describe universe and life as highly coherent systems where in-formation is a key factor and has a fundamental role in their origin. In this vision living systems are cognitive networks in a dynamic relationship with everything around them. Health in this context has to be considered a dynamic balance in a subject in which the information moves on in a correct way. On the contrary diseases have to be identified as pathologies of information, which can be classified in a new way, considering two different codes -semiotic and symbolic- of meaning.
P.M. Biava, A. Nicolini, P. Ferrari, A. Carpi and S. Sell
Abstract: The term “cancer cell reprogramming” is used to define any kind of intervention aimed at transforming cancer cells into terminally differentiated cells. Using this approach, new technologies have been applied with different methods for a more systemic approach to cancer treatment. This review reports on advances of these technologies, including our personal contributions, mainly carried out on endocrine-related cancers. Some of the interventions, aimed at reverting cancer cells into a normal phenotype, are based on the evidence that tumor development is suppressed by the embryonic microenvironment. On the basis of this rationale, experiments have been conducted using stem cell differentiation stage factors (SCDSFs) taken at different stages of development of Zebrafish embryos, oocyte extracts, or naïve human umbili- cal cord matrix derived stem cells (UMDSCs). SCDSFs induce significant growth inhibition on different tumor cell lines in vitro, likely because of increases in cell cycle regulatory molecules, such as p53 and pRb. Treatment with these factors activates apoptosis and differentiation related to caspase-3. This is achieved via p73 apoptotic-dependent pathway activa- tion with a concurrent normalization of the E-cadherin and beta-catenin ratio. Extracts from prophase amphibian oocytes could reprogram relevant epigenetic alterations in MCF-7 and HCC1954 breast cancer cell lines, while un-engineered (na- ïve) human UMDSCs attenuated growth of MDA-231 human breast carcinoma cells. A product prepared for human treatments, containing SCDF at very low doses, yielded favorable results in breast cancer and in intermediate-advanced hepatocellular carcinoma. Other reprogramming interventions used in the models of breast, prostate and ovarian cancer cell lines are described. Finally, current and future perspectives of this novel technology are discussed and a new hallmark of cancer is suggested: the loss of differentiation of cancer cells.
Abstract—Recent researches have shown the theoretical possibility of accomplishing hypercomputation in human brain by using eventual superluminal evanescent photons generated inside brain’s microtubules, using these as quantum waveguides or resonant cavities. Nevertheless, no convincing physical mechanisms has been proposed so far, able to explain the generation of such eventual superluminal photons inside microtubules and the possibility to eventually use them to manipulate quantum bits in brain. In this paper we propose a novel theoretical model according to which a confined field of faster than light photons field of suitable wavelength can arises from a spontaneous phase transition of the QED quantum vacuum occurring in the water contained inside the microtubules inner volume. It has been shown that, in the water trapped inside microtubules, there exist the conditions for the formation of a macroscopic coherent quantum state in which water molecules oscillate in phase with an e,m, field associated to a suitable electronic transition. We have also discussed some interesting consequences of these results on the possibility of hypercomputing in human brain.
Abstract—Several studies have suggested the theoretical possibility of considering human brain as supercomputer using superluminal evanescent photons eventually generated inside its microtubules to manipulate quantum bits in brain. In a previous work we have shown that in the water trapped inside brain microtubules could exist the conditions to allow a spontaneous QED quantum vacuum phase transition towards a macroscopic coherent quantum state characterized by a phased oscillation, at a rescaled frequency, between the water molecules states and an auto-generated electromagnetic field associated to a suitable electronic transition in them. As a result a self-trapped field of superradiant superluminal photons is just generated inside microtubules, characterized by an evanescent tail whose penetration depth is greater than the thickness of microtubules cylinder. In this way the interior of the brain MT cylinders can be considered as a resonant cavity for such superradiant photons whose refraction index depends on the rescaled coherent oscillation frequency. On the other hand it is already theoretical known and experimentally proven that a near perfect tunneling and amplification of evanescent electromagnetic waves is possible in a waveguide filled by a metamaterial. In this paper, basing on the consideration of some structural analogies between man-made metamaterials and some natural biological structures, we just propose the idea to interpret the inner medium of the brain microtubules cylinder as having the properties similar to those characterizing metamaterials and so able to specifically enhance the propagation of evanescent photons inside the neurons.
Foundation of Physics Research Center (FoPRC) Via Resistenza, Celico (CS) ITALY
Abstract: In this paper we show in the water confined within the inner hollow of brain microtubules there exist the conditions to allow a spontaneous QED quantum vacuum phase transition towards a macroscopic coherent quantum state, characterized by a phased oscillation between the water molecules states and an auto-generated electromagnetic field associated to a suitable electronic transition in them. As a result, a field of superradiant photons, whose frequency is smaller than the corresponding frequency belonging to a free photon with the same wavelength, is generated. This superradiant field is characterized by an evanescent tail exceeding the microtubules dimension and whose persistence against environmental decoherence is ensured by its own QED coherent behaviour.