Butyric and Retinoic Mixed Ester of Hyaluronan

A NOVEL DIFFERENTIATING GLYCOCONJUGATE AFFORDING A HIGH THROUGHPUT OF CARDIOGENESIS IN EMBRYONIC STEM CELLSReceived for publication, February 20, 2004, and in revised form, March 16, 2004Published, JBC Papers in Press, March 24, 2004, DOI 10.1074/jbc.M401869200Carlo Ventura, Margherita Maioli, Yolande Asara, Daniela Santoni, Ignazio Scarlata,Silvia Cantoni, and Alberto PerbelliniFrom the Laboratory of Molecular Biology and Stem… Continua a leggere Butyric and Retinoic Mixed Ester of Hyaluronan

Hyaluronan Mixed Esters of Butyric and Retinoic Acid Drive Cardiac and Endothelial Fate in Term Placenta Human Mesenchymal Stem Cells and Enhance Cardiac Repair in Infarcted Rat Hearts

Received for publication, October 3, 2006, and in revised form, March 9, 2007 Published, JBC Papers in Press, March 15, 2007, DOI 10.1074/jbc.M609350200Carlo Ventura, Silvia Cantoni, Francesca Bianchi, Vincenzo Lionetti, Claudia Cavallini, Ignazio Scarlata,Laura Foroni, Margherita Maioli, Laura Bonsi, Francesco Alviano, Valentina Fossati, Gian Paolo Bagnara,Gianandrea Pasquinelli, Fabio A. Recchia, and Alberto PerbelliniFrom the Laboratory… Continua a leggere Hyaluronan Mixed Esters of Butyric and Retinoic Acid Drive Cardiac and Endothelial Fate in Term Placenta Human Mesenchymal Stem Cells and Enhance Cardiac Repair in Infarcted Rat Hearts

Dynorphin B Is an Agonist of Nuclear Opioid Receptors Coupling Nuclear Protein Kinase C Activation to the Transcription of Cardiogenic Genes in GTR1 Embryonic Stem Cells

Carlo Ventura, Elisabetta Zinellu, Emiliana Maninchedda, Margherita MaioliAbstract—The cardiac differentiation of embryonic stem (ES) cells was found to involve prodynorphin gene and dynorphinB expression and was associated with the interaction of secreted dynorphin B with cell surface opioid receptors coupledwith protein kinase C (PKC) signaling and complex subcellular redistribution patterning of selected PKC isozymes.Here, confocal… Continua a leggere Dynorphin B Is an Agonist of Nuclear Opioid Receptors Coupling Nuclear Protein Kinase C Activation to the Transcription of Cardiogenic Genes in GTR1 Embryonic Stem Cells

Protein Kinase C Signaling Transduces Endorphin-Primed Cardiogenesis in GTR1 Embryonic Stem Cells

Carlo Ventura, Elisabetta Zinellu, Emiliana Maninchedda, Marina Fadda, Margherita MaioliAbstract—The prodynorphin gene and its product, dynorphin B, have been found to promote cardiogenesis in embryoniccells by inducing the expression of GATA-4 and Nkx-2.5, two transcription factor– encoding genes essential forcardiogenesis. The molecular mechanism(s) underlying endorphin-induced cardiogenesis remain unknown. In thepresent study, we found that GTR1… Continua a leggere Protein Kinase C Signaling Transduces Endorphin-Primed Cardiogenesis in GTR1 Embryonic Stem Cells

Radiofrequency Energy Loop Primes Cardiac, Neuronal, and Skeletal Muscle Differentiation in Mouse Embryonic Stem Cells: A New Tool for Improving Tissue Regeneration

Margherita Maioli, Salvatore Rinaldi, Sara Santaniello,  Alessandro Castagna,Gianfranco Pigliaru, Sara Gualini, Vania Fontani, and Carlo VenturaDepartment of Biomedical Sciences, University of Sassari, Sassari, ItalyLaboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, Bologna, ItalyRinaldi Fontani Institute, Florence, ItalyMedical School of Occupational Medicine, University of Florence, Florence, ItalyCardiovascular Department, S. Orsola-Malpighi… Continua a leggere Radiofrequency Energy Loop Primes Cardiac, Neuronal, and Skeletal Muscle Differentiation in Mouse Embryonic Stem Cells: A New Tool for Improving Tissue Regeneration