Autore: Michele Grimaldi
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Electronic QED coherence in brain microtubules
LUIGI MAXMILIAN CALIGIURIFoundation of Physics Research Center (FoPRC) Via Resistenza, Celico (CS) ITALYcaligiuri@foprc.org; max.caligiurigmail.comAbstract: In this paper we show in the water confined within the inner hollow of brain microtubules there exist the conditions to allow a spontaneous QED quantum vacuum phase transition towards a macroscopic coherent quantum state, characterized by a phased oscillation between…
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Possible Existence of Superluminal Photons Inside Microtubules and the Resulting Explanation for Brain Mechanism
Takaaki Musha, Luigi Maxmilian CaligiuriD.Georgiev presented an idea that consciousness could be the result of quantum computation via short laser-like pulses controlling quantum gates within the brain cortex. However, he later rejected this theory because the wavelength of super radiant photon emission in the infrared spectrum is two orders of magnitude longer than the size…
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Cancer Cell Reprogramming: Stem Cell Differentiation Stage Factors and An Agent Based Model to Optimize Cancer Treatment
P.M. Biava, M. Basevi, L. Biggiero, A. Borgonovo, E. Borgonovo and F. Burigana The recent tumor research has lead scientists to recognize the central role played by cancer stem cells in sus- taining malignancy and chemo-resistance. A model of cancer presented by one of us describes the mechanisms that give rise to the different kinds…
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Biophysical signalling from and to the (stem) cells: a novel path to regenerative medicine
Carlo Ventura and Luigi Tavazzi1Maria Cecilia Hospital, Gruppo Villa Maria (GVM) Care & Research and Ettore Sansavini Health Science Foundation, Cotignola and Lugo, Ravenna, Italy; and 2Department ofExperimental, Diagnostic and Specialty Medicine, University of Bologna, Italy
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Radio Electric Conveyed Fields Directly Reprogram Human Dermal Skin Fibroblasts Toward Cardiac, Neuronal, and Skeletal Muscle-Like Lineages
Margherita Maioli, Salvatore Rinaldi, Sara Santaniello, Alessandro Castagna,Gianfranco Pigliaru, Sara Gualini, Claudia Cavallini, Vania Fontani, and Carlo VenturaDepartment of Biomedical Sciences, University of Sassari, Sassari, ItalyLaboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, Bologna, ItalyRinaldi Fontani Institute, Florence, Italy§Cardiovascular Department, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, ItalySomatic cells…
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Hyaluronan Mixed Esters of Butyric and Retinoic Acid Affording Myocardial Survival and Repair without Stem Cell Transplantation
Received for publication, November 20, 2009, and in revised form, January 15, 2010 Published, JBC Papers in Press, January 22, 2010, DOI 10.1074/jbc.M109.087254Vincenzo Lionetti, Silvia Cantoni, Claudia Cavallini, Francesca Bianchi, Sabrina Valente, Irene Frascari,Elena Olivi, Giovanni D. Aquaro, Francesca Bonavita, Ignazio Scarlata, Margherita Maioli, Valentina Vaccari,Riccardo Tassinari, Antonietta Bartoli, Fabio A. Recchia, Gianandrea Pasquinelli, and…
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Butyric and Retinoic Mixed Ester of Hyaluronan
A NOVEL DIFFERENTIATING GLYCOCONJUGATE AFFORDING A HIGH THROUGHPUT OF CARDIOGENESIS IN EMBRYONIC STEM CELLSReceived for publication, February 20, 2004, and in revised form, March 16, 2004Published, JBC Papers in Press, March 24, 2004, DOI 10.1074/jbc.M401869200Carlo Ventura, Margherita Maioli, Yolande Asara, Daniela Santoni, Ignazio Scarlata,Silvia Cantoni, and Alberto PerbelliniFrom the Laboratory of Molecular Biology and Stem…
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Hyaluronan Mixed Esters of Butyric and Retinoic Acid Drive Cardiac and Endothelial Fate in Term Placenta Human Mesenchymal Stem Cells and Enhance Cardiac Repair in Infarcted Rat Hearts
Received for publication, October 3, 2006, and in revised form, March 9, 2007 Published, JBC Papers in Press, March 15, 2007, DOI 10.1074/jbc.M609350200Carlo Ventura, Silvia Cantoni, Francesca Bianchi, Vincenzo Lionetti, Claudia Cavallini, Ignazio Scarlata,Laura Foroni, Margherita Maioli, Laura Bonsi, Francesco Alviano, Valentina Fossati, Gian Paolo Bagnara,Gianandrea Pasquinelli, Fabio A. Recchia, and Alberto PerbelliniFrom the Laboratory…
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Dynorphin B Is an Agonist of Nuclear Opioid Receptors Coupling Nuclear Protein Kinase C Activation to the Transcription of Cardiogenic Genes in GTR1 Embryonic Stem Cells
Carlo Ventura, Elisabetta Zinellu, Emiliana Maninchedda, Margherita MaioliAbstract—The cardiac differentiation of embryonic stem (ES) cells was found to involve prodynorphin gene and dynorphinB expression and was associated with the interaction of secreted dynorphin B with cell surface opioid receptors coupledwith protein kinase C (PKC) signaling and complex subcellular redistribution patterning of selected PKC isozymes.Here, confocal…
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Protein Kinase C Signaling Transduces Endorphin-Primed Cardiogenesis in GTR1 Embryonic Stem Cells
Carlo Ventura, Elisabetta Zinellu, Emiliana Maninchedda, Marina Fadda, Margherita MaioliAbstract—The prodynorphin gene and its product, dynorphin B, have been found to promote cardiogenesis in embryoniccells by inducing the expression of GATA-4 and Nkx-2.5, two transcription factor– encoding genes essential forcardiogenesis. The molecular mechanism(s) underlying endorphin-induced cardiogenesis remain unknown. In thepresent study, we found that GTR1…