Protein Kinase C Signaling Transduces Endorphin-Primed Cardiogenesis in GTR1 Embryonic Stem Cells

Carlo Ventura, Elisabetta Zinellu, Emiliana Maninchedda, Marina Fadda, Margherita MaioliAbstract—The prodynorphin gene and its product, dynorphin B, have been found to promote cardiogenesis in embryoniccells by inducing the expression of GATA-4 and Nkx-2.5, two transcription factor– encoding genes essential forcardiogenesis. The molecular mechanism(s) underlying endorphin-induced cardiogenesis remain unknown. In thepresent study, we found that GTR1… Continua a leggere Protein Kinase C Signaling Transduces Endorphin-Primed Cardiogenesis in GTR1 Embryonic Stem Cells