Abstract—Recent researches have shown the theoretical possibility of accomplishing hypercomputation in human brain by using eventual superluminal evanescent photons generated inside brain’s microtubules, using these as quantum waveguides or resonant cavities. Nevertheless, no convincing physical mechanisms has been proposed so far, able to explain the generation of such eventual superluminal photons inside microtubules and the possibility to eventually use them to manipulate quantum bits in brain. In this paper we propose a novel theoretical model according to which a confined field of faster than light photons field of suitable wavelength can arises from a spontaneous phase transition of the QED quantum vacuum occurring in the water contained inside the microtubules inner volume. It has been shown that, in the water trapped inside microtubules, there exist the conditions for the formation of a macroscopic coherent quantum state in which water molecules oscillate in phase with an e,m, field associated to a suitable electronic transition. We have also discussed some interesting consequences of these results on the possibility of hypercomputing in human brain.
Abstract—Several studies have suggested the theoretical possibility of considering human brain as supercomputer using superluminal evanescent photons eventually generated inside its microtubules to manipulate quantum bits in brain. In a previous work we have shown that in the water trapped inside brain microtubules could exist the conditions to allow a spontaneous QED quantum vacuum phase transition towards a macroscopic coherent quantum state characterized by a phased oscillation, at a rescaled frequency, between the water molecules states and an auto-generated electromagnetic field associated to a suitable electronic transition in them. As a result a self-trapped field of superradiant superluminal photons is just generated inside microtubules, characterized by an evanescent tail whose penetration depth is greater than the thickness of microtubules cylinder. In this way the interior of the brain MT cylinders can be considered as a resonant cavity for such superradiant photons whose refraction index depends on the rescaled coherent oscillation frequency. On the other hand it is already theoretical known and experimentally proven that a near perfect tunneling and amplification of evanescent electromagnetic waves is possible in a waveguide filled by a metamaterial. In this paper, basing on the consideration of some structural analogies between man-made metamaterials and some natural biological structures, we just propose the idea to interpret the inner medium of the brain microtubules cylinder as having the properties similar to those characterizing metamaterials and so able to specifically enhance the propagation of evanescent photons inside the neurons.
Foundation of Physics Research Center (FoPRC) Via Resistenza, Celico (CS) ITALY
Abstract: In this paper we show in the water confined within the inner hollow of brain microtubules there exist the conditions to allow a spontaneous QED quantum vacuum phase transition towards a macroscopic coherent quantum state, characterized by a phased oscillation between the water molecules states and an auto-generated electromagnetic field associated to a suitable electronic transition in them. As a result, a field of superradiant photons, whose frequency is smaller than the corresponding frequency belonging to a free photon with the same wavelength, is generated. This superradiant field is characterized by an evanescent tail exceeding the microtubules dimension and whose persistence against environmental decoherence is ensured by its own QED coherent behaviour.
D.Georgiev presented an idea that consciousness could be the result of quantum computation via short laser-like pulses controlling quantum gates within the brain cortex. However, he later rejected this theory because the wavelength of super radiant photon emission in the infrared spectrum is two orders of magnitude longer than the size of any microtubule cavity. To revive this idea of quantum computation within the brain, the authors propose that the substance within a microtubule cylinder has the characteristics of a metamaterial composed of sub-wavelength structures. Using this hypothesis, we can propose the mechanism for human brain based on superluminal photons.
P.M. Biava, M. Basevi, L. Biggiero, A. Borgonovo, E. Borgonovo and F. Burigana
The recent tumor research has lead scientists to recognize the central role played by cancer stem cells in sus- taining malignancy and chemo-resistance. A model of cancer presented by one of us describes the mechanisms that give rise to the different kinds of cancer stem-like cells and the role of these cells in cancer diseases. The model implies a shift in the conceptualization of the disease from reductionism to complexity theory. By exploiting the link between the agent- based simulation technique and the theory of complexity, the medical view is here translated into a corresponding compu- tational model. Two main categories of agents characterize the model, 1) cancer stem-like cells and 2) stem cell differen- tiation stage factors. Cancer cells agents are then distinguished based on the differentiation stage associated with the ma- lignancy. Differentiation factors interact with cancer cells and then, with varying degrees of fitness, induce differentiation or cause apoptosis. The model inputs are then fitted to experimental data and numerical simulations carried out. By per- forming virtual experiments on the model’s choice variables a decision-maker (physician) can obtains insights on the pro- gression of the disease and on the effects of a choice of administration frequency and or dose. The model also paves the way to future research, whose perspectives are discussed.
1Maria Cecilia Hospital, Gruppo Villa Maria (GVM) Care & Research and Ettore Sansavini Health Science Foundation, Cotignola and Lugo, Ravenna, Italy; and 2Department of
Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy
Margherita Maioli, Salvatore Rinaldi, Sara Santaniello, Alessandro Castagna,
Gianfranco Pigliaru, Sara Gualini, Claudia Cavallini, Vania Fontani, and Carlo Ventura
Department of Biomedical Sciences, University of Sassari, Sassari, Italy
Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, Bologna, Italy
Rinaldi Fontani Institute, Florence, Italy
§Cardiovascular Department, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
Somatic cells can be directly reprogrammed to alternative differentiated fates without first becoming stem/
progenitor cells. Nevertheless, the initial need for viral-mediated gene delivery renders this strategy unsafe in
humans. Here, we provide evidence that exposure of human skin fibroblasts to a Radio Electric Asymmetric
Conveyer (REAC), an innovative device delivering radio electric conveyed fields at a radiofrequency of 2.4 GHz,
afforded remarkable commitment toward cardiac, neuronal, and skeletal muscle lineages. REAC induced the
transcription of tissue-restricted genes, including Mef2c, Tbx5, GATA4, Nkx2.5, and prodynorphin for cardiac
reprogramming, as well as myoD, and neurogenin 1 for skeletal myogenesis and neurogenesis, respectively.
Conversely, REAC treatment elicited a biphasic effect on a number of stemness-related genes, leading to early
transcriptional increase of Oct4, Sox2, cMyc, Nanog, and Klf4 within 6–20 h, followed by a downregulation at
later times. The REAC action bypassed a persistent reprogramming toward an induced pluripotent stem celllike
state and involved the transcriptional induction of the NADPH oxidase subunit Nox4. Our results show for
the first time the feasibility of using a physical stimulus to afford the expression of pluripotentiality in human
adult somatic cells up to the attainment of three major target lineages for regenerative medicine.
Received for publication, November 20, 2009, and in revised form, January 15, 2010 Published, JBC Papers in Press, January 22, 2010, DOI 10.1074/jbc.M109.087254
Vincenzo Lionetti, Silvia Cantoni, Claudia Cavallini, Francesca Bianchi, Sabrina Valente, Irene Frascari,
Elena Olivi, Giovanni D. Aquaro, Francesca Bonavita, Ignazio Scarlata, Margherita Maioli, Valentina Vaccari,
Riccardo Tassinari, Antonietta Bartoli, Fabio A. Recchia, Gianandrea Pasquinelli, and Carlo Ventura
From the Sector of Medicine, Scuola Superiore S. Anna, I-56124 Pisa, Italy, the Laboratory of Molecular Biology and Stem Cell
Engineering, Cardiovascular Department-National Institute of Biostructures and Biosystems, S. Orsola-Malpighi Hospital,
University of Bologna, I-40138 Bologna, Italy, the Bioscience Institute, RSM-47891 Falciano, Republic of San Marino, the §Institute
of Clinical Physiology, Consiglio Nazionale delle Ricerche Fondazione G. Monasterio, I-56124 Pisa, Italy, the ‡‡Department of
Biomedical Sciences, University of Sassari, I-07100 Sassari, Italy, the §§Department of Physics, University of Pisa, I-56124 Pisa, Italy,
the Department of Physiology, New York Medical College, Valhalla, New York 10595, and the **Department of Hematology,
Oncology, and Clinical Pathology, University of Bologna, I-40138 Bologna, Italy
A NOVEL DIFFERENTIATING GLYCOCONJUGATE AFFORDING A HIGH THROUGHPUT OF CARDIOGENESIS IN EMBRYONIC STEM CELLS
Received for publication, February 20, 2004, and in revised form, March 16, 2004
Published, JBC Papers in Press, March 24, 2004, DOI 10.1074/jbc.M401869200
Carlo Ventura, Margherita Maioli, Yolande Asara, Daniela Santoni, Ignazio Scarlata,
Silvia Cantoni, and Alberto Perbellini
From the Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and
Biosystems, University of Bologna, I-40138 Bologna, Italy, the Department of Biomedical Sciences, University of Sassari,
I-07100 Sassari, Italy, and the Department of Biochemistry, Biophysics, and Chemistry of Macromolecules, University of
Trieste, I-34127 Trieste, Italy
Received for publication, October 3, 2006, and in revised form, March 9, 2007 Published, JBC Papers in Press, March 15, 2007, DOI 10.1074/jbc.M609350200
Carlo Ventura, Silvia Cantoni, Francesca Bianchi, Vincenzo Lionetti, Claudia Cavallini, Ignazio Scarlata,
Laura Foroni, Margherita Maioli, Laura Bonsi, Francesco Alviano, Valentina Fossati, Gian Paolo Bagnara,
Gianandrea Pasquinelli, Fabio A. Recchia, and Alberto Perbellini
From the Laboratory of Molecular Biology and Stem Cell Engineering, Institute of Cardiology, National Institute of Biostructures
and Biosystems, University of Bologna, I-40138 Bologna, Italy, Department of Experimental Pathology, University of Bologna,
I-40138 Bologna, Italy, Department of Histology, Embryology, and Applied Biology, University of Bologna, I-40138 Bologna, Italy,
Sector of Medicine, Scuola Superiore S. Anna, CNR Institute of Clinical Physiology, I-56124 Pisa, Italy and Department of
Physiology, New York Medical College, Valhalla, New York 10595, and Department of Biomedical Sciences,
University of Sassari, I-07100 Sassari, Italy